Localization of Epileptic Foci

2.  Localization of Epileptic Sources in Surgical Planning by using Deep EEG Electrodes (Derin EEG Elektrotlarının Beyin Dokusuna Yerleştirimine Dayalı Cerrahi Planlamada Epileptik  Bölgelerin Kaynak Görüntülemesi)

Project Coordinator: Prof. Dr. Ahmet Ademoğlu
Researcher: A. Deniz Duru

Project Summary: Epilepsy is one of the most  common diseases related to the disfunctioning of the central nervous system. For the patients whose drug therapy turns out to be ineffective, it is a common method to identify the locations of sources that trigger the seizure in the brain tissue and resect them through surgical means for treatment. When the surgical therapy is to be applied, seizure history, physical and neurological inspections, radiological imaging data (MRI, CT, PET), neuropsychological tests, psychiatric inspections and long term video and EEG monitoring data are evaluated by an expert group of neurosurgeons and neurologists. It requires to locate the epileptic focus using the EEG data recorded from the surface as well as from the deep sites located in the brain in order to improve the  widely  accepted current surgical planning approach. It is critically important to identify the  source locations of seizure activity for the epileptic surgery. This undoubtedly provides  a very important information to the clinical team for the surgical planning. The major aim of this study is to perform source localization using the surface and deep electrode EEG data obtained from epileptic patients and hence, to provide a biomedical support to the surgical planning. As a result, by applying a smaller number of electrodes it is aimed to offer less inconvenience to the patient as well as to reduce significantly the cost and duration of the surgical procedure.

Keywords: EEG source localization, epilepsy, deep/subdural electrode